CECAD Microsite

Research Group "DNA Damage response and Cancer"

Genome maintenance is crucial for the integrity of individual cells and the entire organism. Failure to repair genotoxic lesions leads to an increased mutation frequency and ultimately promotes tumor development. Thus, it is perhaps not surprising that genes involved in DNA damage signaling and DNA repair are among the most frequently altered genes in human cancer. However, defective DNA repair pathways also create molecular liabilities that might be therapeutically exploitable. The research group of Christian Reinhardt aims at discovering novel molecular liabilities using large-scale functional genomics screens. We validate the discoveries derived from our screening platform using biochemical and cell biological approaches, as well as various distinct genetically engineered mouse models of cancer, including models mimicking lung cancer, breast cancer and chronic lymphocytic leukemia. We are closely collaborating with our partners in the clinical departments to actively translate our discoveries into clinical application. The ultimate goal of our work is the development of novel therapeutic approaches for cancer patients.

Lab-News

Anna Schmitt´s paper on the role of ATM in NSCLC has just been accepted at Cancer Research

Anna has generated a mouse model for the inactivation of the DNA damage response kinase ATM in Kras-mutant lung adenocarcinoma

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KinderUni: Goodbye Chemo!

Our Team organised a 2h Workshop on new targeted cancer therapies for children aged 8-12 and their parents

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Tim Rehkämper receives funding through Köln Fortune

Tim Rehkämper receives funding through Köln Fortune

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Johanna Erber receives Mildred-Scheel-Fellowship of Deutsche Krebshilfe

Johanna Erber receives Mildred-Scheel-Fellowship of Deutsche Krebshilfe

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Joachim Steiner receives graduate student fellowship from the DGIM

Joachim Steiner received a prestigious graduate student fellowship from the DGIM, which was awarded at the annual conference of the society.

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Christian Reinhardt receives the Theodor Frerichs Award of the German Society for Internal Medicine

The 2016 Theodor Frerichs Research Award was presented to Christian Reinhardt on Sunday April 10th at the annual Meeting of the German Society for...

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Gero Knittel´s paper on Myd88-driven ABC-DLBCL has just been accepted at Blood

Gero Knittel, together with Paul Liedgens and Darya Korovkina, has developed an autochthonous mouse model of Myd88-driven ABC-DLBCL. This work was...

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Felix Dietlein´s paper on synergistic drug interactions just appeared in Cell.

Felix Dietlein´s paper on synergistic drug interactions just appeared in Cell. With the help of Anna Schmitt, Mladen Jokic, Bastian Kalb, Alessandro...

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Gero Knittel´s review is online

Gero Knittel`s review on targeting DNA repair defects in CLL is online now.

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Darya Korovkina and Miriam Rinneburger receive funding through Köln Fortune

Both Darya Korovkina and Miriam Rinneburger have been awarded with a Köln Fortune grant for medical students.

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