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The paper “Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia” with contributions from Anna Schmitt, Ron Jachimowicz and Roberta Castiglione is published.

02/26/2018

Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analysed whole-exome sequencing data of eight chronic lymphocytic leukemia (CLL) patients that developed resistance upon BCL2-inhibition by venetoclax. Here, Anna Schmitt, Ron Jachimowicz, Roberta Castiglione and colleagues report recurrent mutations in BTG1 (2 patients) and homozygous deletions affecting CDKN2A/B (3 patients) that developed during treatment, as well as a mutation in BRAF and a high-level focal amplification of CD274 (PD-L1) that might pinpoint molecular aberrations offering structures for further therapeutic interventions.